NCT07028905

Deep Caries in Mature Teeth With Reversible Pulpitis

Clinical, Radiographical, and Histological Evaluation of Treatment Outcomes Following Different Caries Removal Strategies in Mature Permanent Teeth With Reversible Pulpitis (A Randomized Clinical Trial and Ex-vivo Study)

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 144 (estimated)
• Sponsor: Minia University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This clinical trial will be conducted to clinical, radiographical and histological evaluation of pulp condition with reversible pulpities after total and selective removal of primary and secondary caries (randomized clinical trial and exo-vivo study)

Detailed description

Randomized clinical trial Sample size 144 case… Randomization method used: Sample size calculation was performed using R statistical analysis software version 4.3.2 for Windows Outcome variables: Pulp vitality and post operative pain Grouping classified into four groups as follows: The first group : total caries removal of primary caries(PTCR) 27 The second group: selective caries removal of primary caries(PSCR) The third group: total caries removal of secondary caries(STCR) The fourth group : selecive caries removal of secondary caries(SSCR) Expected Time table: 2 years Recall of patient after 3,6,9 and 12 months 6 months for writing and 6 months for data analyzed

Conditions

• Deep Caries

Interventions

Type	Name	Description
PROCEDURE	Total caries removal	Total caries removal and application of bioactive material
PROCEDURE	Partial caries removal	Partial caries removal then application of biodentin

Timeline

• Start date: 2025-10-20
• Primary completion: 2026-10-20
• Completion: 2026-12-01
• First posted: 2025-06-19
• Last updated: 2025-09-26