NCT07028567

Subcision Followed by Diluted Calcium Hydroxylapatite Injection Versus Subcision Followed by Painting CROSS TCA Technique for the Treatment of Atrophic Acne Scars

Comparative Study of Subcision Followed by Diluted Calcium Hydroxylapatite Injection Versus Subcision Followed by Painting CROSS TCA Technique for the Treatment of Atrophic Acne Scars

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to compare the safety and efficacy of subcision followed by diluted calcium hydroxyapatite injection versus subcision followed by the painting original chemical reconstruction of skin scars (CROSS) technique using trichloroacetic acid (TCA) for the treatment of atrophic acne scars.

Detailed description

Atrophic scars present as depressions secondary to fibrous contractions. Subcision is a technique in which a needle is inserted under the acne scar to sever the fibrous tissue (tethers) that bind down the scar. This releases the fibrous tissue. The original chemical reconstruction of skin scars (CROSS) technique using trichloroacetic acid (TCA) entails focal application of highly concentrated TCA (70% to 100%) with firm pressure applied to the entire atrophic area using a sharpened wooden applicator until frosting occurs. Fillers containing hyaluronic acid, calcium hydroxyapatite, and poly-L-lactic acid are increasingly used to correct atrophic acne scarring as they augment soft tissue in variable degree and are most effective in soft rolling or boxcar scars.

Conditions

• Subcision
• Calcium Hydroxylapatite
• Trichloroacetic Acid
• Atrophic Acne Scar

Interventions

Type	Name	Description
DRUG	Calcium hydroxylapatite filler	Patients received calcium hydroxylapatite filler (CaHA) (Radiesse®).
DRUG	Painting chemical reconstruction of skin scars trichloroacetic acid technique	Patients received painting chemical reconstruction of skin scars (CROSS) trichloroacetic acid (TCA) technique.

Timeline

• Start date: 2023-01-01
• Primary completion: 2023-06-22
• Completion: 2023-06-22
• First posted: 2025-06-19
• Last updated: 2025-06-19

Locations

1 site across 1 country: Egypt