NCT07027566

Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity

Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity Induced by Tooth Bleaching

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Universidade Federal do Para · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial will be to evaluate the effect applying an experimental gel based on cannabidiol oil (CBD) on tooth sensitivity induced by tooth bleaching with 35% hydrogen peroxide (HP). Volunteers will be selected and allocated to the following groups: GP - placebo gel, GCBD - experimental cannabidiol gel and GKF - Potassium Nitrate and Sodium Fluoride Gel. In each group, the corresponding desensitizing gel will be applied to on the teeth for 10 minutes. All groups will then undergo in-office whitening treatment with 35% hydrogen peroxide. Patients will be instructed to record tooth sensitivity on a daily basis during the 21 days of follow-up. Pain intensity will be measured using a visual analog scale (VAS), while the risk of developing sensitivity will be recorded after each session of the whitening procedure, with two response option.

Conditions

• Dentin Sensitivity

Interventions

Type	Name	Description
DRUG	Potassium nitrate and sodium fluoride	Gel with 5% potassium nitrate and 2% sodium fluoride gel of 5% potassium nitrate and 2% sodium fluoride for topical application to teeth before bleaching with hydrogen peroxide
DRUG	Cannabidiol (CBD) Gel	Cannabidiol gel for teeth ( 2% cannabidiol oil) before bleaching with hydrogen peroxide
DRUG	Natrosol 4% Gel	placebo gel (natrosol-based gel 4%) for topical application to teeth before bleaching with hydrogen peroxide.

Timeline

• Start date: 2025-07-25
• Primary completion: 2026-05-01
• Completion: 2026-07-01
• First posted: 2025-06-18
• Last updated: 2025-06-18

Locations

1 site across 1 country: Brazil