NCT07027033

Nutritional Oleic Acid Modulation of adIpose Cholesterol Metabolism in Patients Living With Obesity

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Nantes University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Disruption of white adipose tissue (WAT) homeostasis during obesity is central to the development of associated cardiometabolic complications. Dietary supplementation with oleic acid in obese patients can limit these complications. Experimental data, obtained in preclinical models, suggest that the beneficial effects of oleic acid may protect the TAB by increasing cholesterol esterification. The NAMICO study aims to test this hypothesis using TAB biopsies collected from obese patients undergoing bariatric surgery who had previously undergone dietary enrichment with either a conventional oil or an oil rich in oleic acid.

Conditions

• Obesity
• Visceral Adipose Tissue
• White Adipose Tissue Inflammation
• Subcutaneous Adipose Tissue

Interventions

Type	Name	Description
OTHER	acid-rich sunflower oil oleic acid	Nutritional intervention for 13 weeks ± 2 weeks, including 40 millilitres of sunflower oil rich in oleic acid
OTHER	conventional sunflower oil	Nutritional intervention for 13 weeks ± 2 weeks, including 40 millilitres of conventional sunflower oil

Timeline

• Start date: 2025-07-15
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2025-06-18
• Last updated: 2026-01-15

Locations

1 site across 1 country: France