NCT07026825

Surgical Resection Enhances Survival in Gastric-type Endocervical Adenocarcinoma: A SEER-Based Study

Surgical Resection Improves Survival in Gastric-type Endocervical Adenocarcinoma: A SEER-Based Propensity-Matched Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 308 (actual)
• Sponsor: Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This retrospective cohort study analyzes the effect of surgical resection on survival outcomes in patients with gastric-type endocervical adenocarcinoma (GAS), using data from the SEER database (2000-2021). Propensity score matching and multivariable Cox regression were used to compare overall survival (OS) and tumor-specific survival (TSS) between patients who underwent surgery and those who did not. The study aims to determine whether primary tumor resection is associated with improved survival across tumor sizes and stages.

Detailed description

The study utilized de-identified data from the SEER program encompassing women aged ≥18 with histologically confirmed gastric-type endocervical adenocarcinoma between 2000 and 2021. The primary endpoints were overall survival and tumor-specific survival. Statistical analyses included multivariable Cox regression, propensity score matching (2:1), and inverse probability of treatment weighting (IPTW). Subgroup analyses were performed based on FIGO stage and tumor size (\>4 cm). A total of 308 eligible cases were included. No patient interaction or clinical intervention occurred.

Conditions

• Gastric-type Endocervical Adenocarcinoma

Timeline

• Start date: 2000-01-01
• Primary completion: 2021-12-30
• Completion: 2022-12-30
• First posted: 2025-06-18
• Last updated: 2025-06-18