NCT07026799

Feasibility, Safety and Effectivity of an Exercise Intervention for Newly Diagnosed Multiple Myeloma Patients During Induction Therapy

Investigation of an Exercise Intervention for Multiple Myeloma Patients With Stable and Unstable Osteolytic Lesions During Induction Therapy.

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University Hospital Heidelberg · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Physical exercise is an important supportive therapy for cancer patients, which improves quality of life and can effectively counteract the side effects of drug therapy. There is very little experience whether physical activity can also be performed safely by patients with malignant diseases that affect bone stability. This applies in particular to patients with multiple myeloma, a disease characterized by a monoclonal proliferation of plasma cells in the bone marrow and often accompanied by severe bony destruction. Aim of this exploratory randomized controlled trial is to evaluate feasibility, safety and effectivity of an orthopaedic-guided exercise intervention during induction therapy in newly diagnosed multiple myeloma patients.

Conditions

• Multiple Myeloma Bone Lesions

Interventions

Type	Name	Description
OTHER	Exercise	Orthopedic consultation and home-based, individualized, structured resistance training during induction therapy.
OTHER	Control group	Orthopedic consultation and stretching exercises/walking. No resistance training.

Timeline

• Start date: 2023-04-14
• Primary completion: 2026-06-27
• Completion: 2026-06-27
• First posted: 2025-06-18
• Last updated: 2025-06-18

Locations

1 site across 1 country: Germany