Trials / Not Yet Recruiting
Not Yet RecruitingNCT07025824
Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation
Randomized Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation
- Status
- Not Yet Recruiting
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 220 (estimated)
- Sponsor
- Technische Universität Dresden · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this study is to compare the effectiveness and tolerability of two conditioning chemotherapies prior to allogeneic stem cell transplantation. The following will also be investigated: * Survival * Remission and Relapse rate * Engraftment or graft failure * Graft versus Host Disease (GvHD)
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Treosulfan (Treo) | 10 g/m2 intravenous |
| DRUG | Melphalan (Mel) | 140 mg/m2 intravenous |
| DRUG | Fludarabine (Flud) | 30 mg/m2 intravenous |
Timeline
- Start date
- 2025-09-01
- Primary completion
- 2028-12-01
- Completion
- 2028-12-01
- First posted
- 2025-06-18
- Last updated
- 2025-09-03
Locations
4 sites across 1 country: Germany
Source: ClinicalTrials.gov record NCT07025824. Inclusion in this directory is not an endorsement.