NCT07025759

Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 18 (estimated)
• Sponsor: Universidade Federal de Pernambuco · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Detailed description

This clinical trial is a crossover trial comparing 9 single-session rPMS protocols over the extensor carpi radialis muscle, testing three frequencies (1Hz, 10Hz, 25Hz), intensities (90%, 100%, 110% of resting motor threshold) across sequential phases. Participants: Healthy adults (18-40 years) undergo pre-/post-intervention assessments: cortical (MEPs, ICI/ICF) excitability. Design: Crossover, double-blind. Analysis: ANOVA or Friedman tests (SPSS v20.0; α=0.05). Significance: Clarifies parameter-specific neuromodulatory effects, guiding future rehabilitation protocols for neurological conditions. Ethics: Approved by Federal University of Pernambuco's ethics committee (Resolution 466/12). Data stored securely for 5 years.

Conditions

• Healthy Individuals

Interventions

Type	Name	Description
DEVICE	Peripheral magnetic stimulation (90% of RMT + 1 Hz)	Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
DEVICE	Peripheral magnetic stimulation (90% of RMT + 10 Hz)	High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses.
DEVICE	Peripheral magnetic stimulation (90% of RMT + 25 Hz)	High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses.
DEVICE	Peripheral magnetic stimulation (100% of RMT + 1 Hz)	Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
DEVICE	Peripheral magnetic stimulation (100% of RMT + 10 Hz)	High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
DEVICE	Peripheral magnetic stimulation (100% of RMT + 25 Hz)	High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
DEVICE	Peripheral magnetic stimulation (110% of RMT + 1Hz)	Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
DEVICE	Peripheral magnetic stimulation (110% of RMT + 10Hz)	High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
DEVICE	Peripheral magnetic stimulation (110% of RMT + 25Hz)	High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.

Timeline

• Start date: 2022-10-01
• Primary completion: 2025-09-01
• Completion: 2025-10-01
• First posted: 2025-06-17
• Last updated: 2025-06-17

Locations

1 site across 1 country: Brazil