NCT07021079

Muscle Vibration as a Countermeasure Against Hypoactivity-induced

Effects of Focal Muscle Vibration as a Countermeasure Against Hypoactivity-induced Neuromuscular Deconditioning

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 19 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Muscle deconditioning, characterized by a loss of muscle mass and strength, is a frequent consequence of prolonged lower limb unloading. Beyond muscle mass loss, reduced neural drive contributes significantly to strength decline, highlighting the need for interventions targeting neuromuscular function during immobilization. Focal muscle vibration (FMV) has shown promise in modulating neuromuscular excitability by activating muscle spindle afferents and inducing cortical adaptations. Chronic use of FMV has been associated with significant strength gains and improved neural command. This makes FMV an effective rehabilitation tool. Its simplicity and non-invasiveness further make it a practical countermeasure.

Detailed description

This study hypothesizes that a 10-day FMV protocol can induce neural adaptations to limit strength loss during unilateral lower limb suspension, offering a novel strategy against neuromuscular function decline.

Conditions

• Vibration Therapy
• Healthy Volunteer Study
• Hypoactivity

Interventions

Type	Name	Description
DEVICE	Focal muscle vibration	focal muscle vibration sessions, using small and portable vibrator devices.
DEVICE	NO Focal muscle vibration	The control group will not receive any intervention.

Timeline

• Start date: 2025-06-16
• Primary completion: 2027-06-01
• Completion: 2027-08-31
• First posted: 2025-06-13
• Last updated: 2025-11-26

Locations

1 site across 1 country: France