NCT07020546

Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score

Ovarian Platelet-Rich Plasma (oPRP) Injections Improvement In IVF Patients Based On Time-Lapse Incubator Culture for Automated Tracking and AI for Embryo Quality Assessment : A Non-Randomized Propsective Self-Controlled Interventional Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Generation Next Fertility · Academic / Other
• Sex: Female
• Age: 18 Years – 47 Years
• Healthy volunteers: Accepted

Summary

Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.

Detailed description

. oPRP Treatment \& Second IVF Cycle (Study Cycle) * Following the first IVF cycle, patients will undergo their first oPRP injection: * Timing: 1-2 weeks after the onset of the next menstrual cycle. * Procedure: Under IV sedation, a patient's autologous PRP will be prepared and injected directly into both ovaries under transvaginal ultrasound guidance. * Second IVF Cycle (oPRP Study Cycle) * The same ovarian stimulation protocol will be used for consistency. * A second oPRP injection will be performed on stimulation days 2-5 to enhance folliculogenesis. * Ovulation will be triggered at the same follicular size thresholds, and oocyte retrieval will follow identical protocols. * Fertilization methodology will be identical to the first cycle unless no fertilization is identified in the first cycle. * Embryo Development Analysis: Up to 15 embryos will be cultured in the AI incubator, where time-lapse imaging will track their morphokinetics, and AI-based analysis will assess embryo viability and implantation potential.

Conditions

• Infertility
• Poor Ovarian Reserve
• Embryo Growth Disorder
• in Vitro Fertilization

Interventions

Type	Name	Description
PROCEDURE	Ovarian Platelet-rich plasma (PRP) injections	This is a procedure that our patients receive at our clinic. We want to use the AI software to evaluate embryo development before and after treatment to see if there is a difference in embryo quality after PRP treatment within the same patient.

Timeline

• Start date: 2025-07-08
• Primary completion: 2026-06-30
• Completion: 2026-08-30
• First posted: 2025-06-13
• Last updated: 2025-07-09

Locations

1 site across 1 country: United States