NCT07019909

A Study to Learn About How Safe and Effective is 20vPnC and 13vPnC Vaccines in Chinese Adults

A Phase 1, Randomized, Double-Blind, Third-Party-Unblinded Trial to Evaluate the Safety and Immunogenicity of 20-valent Pneumococcal Conjugate Vaccine (20vPnC) and 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Pneumococcal Vaccine-Naïve Adults 50 Years of Age and Older in China

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 400 (actual)
• Sponsor: Pfizer · Industry
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

This Phase 1, randomized, double-blind, third-party-unblinded study will be conducted at investigational sites in China. The purpose of the study is to learn about the safety and immune response of 20vPnC and 13vPnC in Chinese adults 50 years of age and older who did not receive any of pneumococcal vaccine in the past

Detailed description

The purpose of the study is to learn about the safety and immune response of 20vPnC and 13vPnC vaccines in Chinese adults. This study is seeking for participants who: * are 50 years of age and older * did not receive any of vaccines used to treat infections caused by the bacteria called Streptococcus pneumonia in the past. The participants will be grouped by three age groups: * Adults between 50 to 59 years of age * Adults between 60 to 64 years of age * Adults who are 65 years of age or above All participants in this study will receive a single dose of 20vPnC or 13vPnC at study clinic. The study will look at the experiences of people receiving 20vPnC and 13vPnC. This will help decide if the study vaccine is safe. The total duration of taking part in the study will be around 6 months, with 6 visits.

Conditions

• Pneumococcal Disease

Interventions

Type	Name	Description
BIOLOGICAL	20vPnC	20 valent pneumococcal conjugate vaccine
BIOLOGICAL	13vPnC	13 valent pneumococcal conjugate vaccine

Timeline

• Start date: 2025-07-06
• Primary completion: 2026-01-28
• Completion: 2026-01-28
• First posted: 2025-06-13
• Last updated: 2026-02-25

Locations

3 sites across 1 country: China