NCT07019519

POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS

Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.

Detailed description

Each participant will attend independent randomized experimental days with MR-scans during and intravenous infusions of hormones or placebo and ingestion of glucose or water. A continuous intravenous infusion of either GIP(3-30)NH2, CCK8- or saline for POTS-group or GIP(3-30)NH2, CCK-8, saline or exendin(9-39)NH2 in healthy is started while the participant lie in the scanner while scans, blood samples and questionnaires are repeated over the time course of 2 hours. At a specific timepoint the participants will ingest 75 g of glucose dissolved in 250 ml water.

Conditions

• Postural Orthostatic Tachycardia Syndrome (POTS)
• Healthy

Interventions

Type	Name	Description
OTHER	Saline/Placebo	NaCl(9mg/ml)
OTHER	GIPR antagonist	GIP(3-30)NH2
OTHER	GLP-1R antagonist	GLP-1(9-39)NH2
OTHER	CCK agonist	CCK-8

Timeline

• Start date: 2025-03-15
• Primary completion: 2026-06-30
• Completion: 2026-09-30
• First posted: 2025-06-13
• Last updated: 2025-06-13

Locations

1 site across 1 country: Denmark