Trials / Not Yet Recruiting
Not Yet RecruitingNCT07017803
Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 460 (estimated)
- Sponsor
- Centre de Recherche Médicale de Lambaréné · Academic / Other
- Sex
- All
- Age
- 9 Years
- Healthy volunteers
- Accepted
Summary
Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge in Central Africa. Understanding the molecular epidemiology and genotypic characteristics of MDR-TB strains is crucial for effective control measures. This is highlighted by the emergence of mutations encoding resistance to bed aquiline and quinolones which may impact the roll out of the newly recommended Bedaquiline, Pretomanid, Linezolid and Moxifloxacin (BPaLM) regimens. It is also worth noting that there is increasing evidence of the significance of TB lineage in the outcome of infection, the approach in the study will provide both information on chains of transmission and lineage.
Conditions
- Tuberculosis, Multi Drug Resistant
- Strains
- Molecular Epidemiology
- Multi Drug Resistant Tuberculosis
- Central Africa
Timeline
- Start date
- 2025-07-01
- Primary completion
- 2025-11-30
- Completion
- 2026-01-31
- First posted
- 2025-06-12
- Last updated
- 2025-06-12
Source: ClinicalTrials.gov record NCT07017803. Inclusion in this directory is not an endorsement.