NCT07016529

Diagnostic Study for Differentiating Functional From Organic Diseases in Patients With Lower GIT Symptoms

Diagnostic Utility of Myeloperoxidase for Differentiating Irritable Bowel Syndrome From Inflammatory Bowel Disease in Patients With Lower GIT Symptoms

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The study is intended to find a new trusted, cost-effective biomarker for differentiating irritable bowel syndrome from inflammatory bowel disease to decrease the use of unnecessary invasive methods in patients with irritable bowel syndrome

Detailed description

Myeloperoxidase is a lysosomal protein that is released from granules of neutrophil granulocytes during inflammation. the study design relies on the fact that there is no mucosal inflammation in case of functional gastrointestinal tract (GIT) disorders like irritable bowel syndrome (IBS), but organic gastrointestinal conditions like inflammatory bowel diseases (IBD) has mucosal inflammation and neutrophil influx into the mucosa. the study is designed to assess myeloperoxidase levels in both conditions and assessing its reliability in differentiation between them.

Conditions

• Irritable Bowel Syndrome (IBS)
• Inflammatory Bowel Disease (IBD)

Timeline

• Start date: 2025-06-10
• Primary completion: 2025-12-10
• Completion: 2025-12-20
• First posted: 2025-06-11
• Last updated: 2025-06-11