Trials / Active Not Recruiting
Active Not RecruitingNCT07016334
We Analyse Metabolites in Dried Blood Spots From Newborns That Later in Life Developed an Eating Disorder.
The Role of Metabolic, Immune, and Neurotrophic Markers in the Etiology of Eating Disorders Using Neonatal Bloodspots
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 3,000 (actual)
- Sponsor
- Karolinska Institutet · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Anorexia nervosa (AN) and bulimia nervosa (BN) are serious eating disorders (EDs) with significant morbidity and mortality. Genetic studies have shown associations between EDs and metabolic traits, and longitudinal studies indicate distinct weight trajectories in children who later develop AN or BN, suggesting early involvement of metabolic factors. Biological studies also reveal differences in immune and neurotrophic markers in individuals with EDs compared to controls. Intriguingly, metabolites measured in neonatal blood could serve as very early markers of ED risk, unconfounded by state or scar factors related to prolonged starvation. Here the investigators propose to comprehensively analyze neonatal biomarkers (metabolic, immune, and neurotrophic), epidemiological factors, and genetics to understand ED risk and develop risk prediction models
Conditions
Timeline
- Start date
- 2022-09-01
- Primary completion
- 2026-12-01
- Completion
- 2027-12-01
- First posted
- 2025-06-11
- Last updated
- 2025-06-11
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT07016334. Inclusion in this directory is not an endorsement.