NCT07015645

Long-Term Outcomes of Hypopituitarism Following Gamma Knife Radiosurgery for Pituitary Adenomas

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 137 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to assess long-term outcomes of hypopituitarism following gamma knife radiosurgery (GKRS) for pituitary adenomas.

Detailed description

Pituitary adenomas (PAs) are one of the most common intracranial neoplasms, accounting for 10-20% of diagnosed brain tumors. Initial gamma knife radiosurgery (GKRS) can be an alternative treatment for selected NFPA patients with comorbidities, documented growth small tumors, cavernous sinus invasion, or advanced age. Hypopituitarism is one of the most common complications of radiosurgery (Cordeiro et al., 2018). Long-term follow-up is crucial to assess new pituitary deficits. Typically, hypopituitarism presents within the first 2-4 years after the treatment with radiosurgery, but the risk of pituitary insufficiency increases to up to 80%. Reports on the highest incidence of new-onset hypopituitarism also mentioned the longest follow-up period.

Conditions

• Long Term
• Hypopituitarism
• Gamma Knife Radiosurgery
• Pituitary Adenomas

Interventions

Type	Name	Description
PROCEDURE	Gamma Knife Radiosurgery	Patients received gamma knife radiosurgery (GKRS) treatment for pituitary adenomas.

Timeline

• Start date: 2019-01-01
• Primary completion: 2025-01-01
• Completion: 2025-01-01
• First posted: 2025-06-11
• Last updated: 2025-06-11

Locations

1 site across 1 country: Egypt