Trials / Not Yet Recruiting
Not Yet RecruitingNCT07015060
Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic Sclerosis
- Status
- Not Yet Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- Sponsor
- Université Catholique de Louvain · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Accepted
Summary
Identify rare variants in candidate genes and pathways identified in familial SSc, in patients with sporadic SSc. Perform (spatial) transcriptomic and proteomic analyses of affected skin from patients with and without cutaneous fibrosis, for the patterns and levels of expression/activation of candidate genes and pathways. Test for dysregulation of expression/activation of candidate genes and pathways in live cells isolated from the blood and skin biopsy of patients, and for the impact of these dysregulations on cell appearance, behavior and function.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | cutaneous biospy | cutaneous biospy |
Timeline
- Start date
- 2025-06-01
- Primary completion
- 2030-09-01
- Completion
- 2031-03-01
- First posted
- 2025-06-11
- Last updated
- 2025-06-11
Source: ClinicalTrials.gov record NCT07015060. Inclusion in this directory is not an endorsement.