NCT07014397

Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic Teeth

Effect of Oral Valaciclovir on Inter- Appointment Endodontic Pain in Single-Rooted Necrotic Teeth With Symptomatic Apical Periodontitis: A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Tehran University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Aim: To investigate the effect of oral valacyclovir on inter-appointment endodontic pain in single-rooted necrotic teeth diagnosed with symptomatic apical periodontitis (SAP). Materials and Methods: This study was a randomized, triple-blind, placebo-controlled clinical trial conducted on 38 teeth. Participants were assigned to intervention or control groups using stratified randomization based on gender and baseline pain severity. Both groups received similar root canal treatment; the only difference was the administration of valacyclovir in the intervention group and placebo in the control group. Patients' pain levels were monitored and recorded at 6, 24, and 48 hours post-treatment using a Visual Analog Scale (VAS), along with their consumption of analgesic (ibuprofen).

Conditions

• Symptomatic Apical Periodontitis

Interventions

Type	Name	Description
DRUG	Valacyclovir	valacyclovir group received 2 g (two 1 g tablets) one hour prior to treatment, followed by 2 g 12 hours later, and 1 g at both 24 and 36 hours post-treatment
DRUG	Placebo	The control group received a placebo identical in appearance and administration schedule

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-03-22
• Completion: 2025-03-26
• First posted: 2025-06-11
• Last updated: 2025-06-11

Locations

1 site across 1 country: Iran