NCT07012811

Treatment of Plane Warts With Topical and Oral Retinoids

Evaluation of Topical Tretinoin 0.05% Alone Versus Combination With Oral Isotretinoin (0.5 mg/kg/Day) in the Treatment of Plane Warts

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: Tishreen University · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study was to compare the effectiveness and safety of topical tretinoin cream 0.05% alone against combination with oral isotretinoin (0.5 mg/kg/day) for treatment of plane warts.

Detailed description

This study included 39 patients divided into two groups. Treatment was given for three months duration. Patients were followed-up for further three months to assess the recurrence rate. Combination treatment led to a faster resolution and a higher percentage of complete response. It presents a promising effective alternative option for treatment of plane warts.

Conditions

• Plane Warts

Interventions

Type	Name	Description
DRUG	Topical tretinoin 0.05%	Topical tretinoin cream 0.05% applied once daily at night
DRUG	Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day)	Topical tretinoin cream 0.05% once daily at night + oral isotretinoin capsule in the dose of 0.5 mg/kg/day

Timeline

• Start date: 2024-02-12
• Primary completion: 2025-03-30
• Completion: 2025-03-30
• First posted: 2025-06-10
• Last updated: 2025-06-10

Locations

1 site across 1 country: Syria