NCT07005804

Calcium Pyrophosphate Deposition (CPPD) Disease

Calcium Pyrophosphate Deposition (CPPD) Disease : Clinical and Paraclinical Profile, Gene Expression and Metabolomics of the Acute and Chronic Clinical Phenotype

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 137 (estimated)
• Sponsor: Lille Catholic University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to describe the transcriptomic and metabolomic profile of patients with chronic Calcium Pyrophosphate Deposition (CPPD) compared to those with acute CPPD. The hypotheses are as follows : * It is hypothesised that there is a transcriptomic and metabolomic signature of CPPD which explains why therapeutic responses to different anti-inflammatory treatments differ from one phenotype to another one * It is hypothesised that the acute and chronic clinical phenotypes of CPPD have different clinical, biological and imaging characteristics, as well as a differing predisposition toward crystalline deposition and inflammatory pathway activation. The management of participants with chronic forms of the disease included in this research was modelled on the usual recommended management, including a biological workup, joint puncture, ultrasound and radiographic workup. Double-energy CT scans and transcriptomic and metabolomic analyses on plasma are not routine tests.

Conditions

• Calcium Pyrophosphate Deposition Disease
• Rheumatic Diseases

Interventions

Type	Name	Description
GENETIC	transcriptomic and metabolomic analysis	Venous blood samples for transcriptomic and metabolomic analysis will be taken in 3 x 4 mL ethylenediaminetetraacetic acid (EDTA) tubes and stored immediately at 4°C, before being cryopreserved at -80°C in 500 μL aliquots of plasma. In addition, for transcriptomic analysis, a sample will also be taken in a Paxgen RNA tube cryopreserved at -80°C.

Timeline

• Start date: 2025-10-01
• Primary completion: 2027-05-01
• Completion: 2027-11-01
• First posted: 2025-06-05
• Last updated: 2025-06-05

Locations

1 site across 1 country: France