NCT07005037

Swallowing Impairments in ICU Survivors and Community-Dwelling Adults

Improving Recovery in Older ICU Survivors: Evaluation of Swallowing Dysfunction and Aspiration Risk

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 460 (estimated)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Post-intensive care syndrome (PICS), which consists of physical, cognitive, and psychosocial problems, is a pervasive complication for older intensive care unit (ICU) survivors and contributes to detrimental health outcomes and significant reductions in quality of life. Yet, little is known about the relationship between PICS, swallowing difficulties (dysphagia), and other ICU-related negative outcomes such as frailty and Alzheimer's Disease and Related Dementias (ADRD). The primary purpose of this research study is to determine the prevalence and severity of dysphagia, risk factors for dysphagia development, recovery patterns of dysphagia over time, and the impact of dysphagia on health outcomes, quality of life, and care partner burden in adult ICU survivors with PICS.

Detailed description

This study will involve one in-person research visit for community dwelling adults and two research visits for critically ill adults (one in the ICU, one 3-months post-hospital discharge) that will last approximately 1 hour and will consist of a screening, cough testing, swallow function testing, assessments of hand grip and tongue strength, and completion of questionnaires. Caregivers of ICU survivors will complete questionnaires at the 3-month follow up visit.

Conditions

• Dysphagia
• Healthy Aging
• Post Intensive Care Syndrome
• Caregiver Burden

Timeline

• Start date: 2027-04-01
• Primary completion: 2029-07-30
• Completion: 2030-07-30
• First posted: 2025-06-04
• Last updated: 2026-03-03

Locations

1 site across 1 country: United States