NCT07001163

Assessment of the Role of Probiotics in Prevention of Ventilator-Associated Pneumonia in Neonates

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Lamiaa Khaled Zidan · Academic / Other
• Sex: All
• Age: 1 Day – 28 Days
• Healthy volunteers: Not accepted

Summary

Evaluate the preventive value of probiotics on VAP among ventilated neonates.

Detailed description

MV is a critical component of neonatal intensive care, providing essential respiratory support for neonates with severe respiratory distress. However, its use is associated with an increased risk of VAP, a serious nosocomial lung infection. VAP is defined as a pneumonia diagnosed in patients undergoing MV for at least 48 hours and is recognized as the second most common nosocomial infection in neonatal and pediatric intensive care units. Its incidence ranges from 1 to 63 episodes per 1,000 ventilation days, with variability influenced by the socioeconomic and healthcare development of different regions.Given the complex pathophysiology of VAP, numerous prevention strategies have been proposed for NICUs.Among these strategies, probiotics have emerged.

Conditions

• Ventilator Acquired Pneumonia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic	Probiotic sachets contained 1× 109 colony-forming unit of Bifidobacterium Animalis subsp.lactis BB-12), were given via orogastric tube twice daily.

Timeline

• Start date: 2023-05-01
• Primary completion: 2024-05-01
• Completion: 2024-06-01
• First posted: 2025-06-03
• Last updated: 2025-06-03

Locations

1 site across 1 country: Egypt