NCT07000201

Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial

the Sedative Efficacy of Preoperative Pregablin Versus Gabapentin in Elderly Undergoing Abdominopelvic Surgery : a Randomized Controlled Clinical Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 84 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Several studies have evaluated the efficacy of pregabalin in reducing preoperative anxiety, with inconsistent results. Similarly, inconclusive results have been reported regarding gabapentin and its effects in reducing preoperative anxiety. A previous study reported that a single dose of gabapentin or pregabalin administered 60 minutes before surgery in adults under general anesthesia was effective in reducing acute preoperative anxiety and elevated levels of sedation before and after surgery, with pregabalin having better anxiolytic and sedative effects than gabapentin. However, no previous studies have compared the efficacy of preoperative pregabalin or gabapentin as premedication to reduce intraoperative anxiety and induce sedation in geriatric patients undergoing major surgery with regional anesthesia

Conditions

• Anxiety
• Anxiety Disorder (Panic Disorder or GAD)

Interventions

Type	Name	Description
DRUG	One hour prior to admission to the operating room, patients will receive the study medication (as premedication) by mouth with a sip of water;	group I patients will receive two capsules of pregabalin (Lyrica) 75 mg (total = 150 mg), group II patients will receive two capsules of gabapentin (Conventin) 300 mg (total = 600 mg), and group III patients will receive a matching placebo in the form of two capsules of powdered multivitamin by mouth.

Timeline

• Start date: 2025-09-15
• Primary completion: 2025-12-15
• Completion: 2025-12-30
• First posted: 2025-06-02
• Last updated: 2025-07-04

Locations

1 site across 1 country: Egypt