NCT06996106

Outcomes of PRF on Septoplasty in Patient With Nasal Septal Deviation

Effect of Platelet Rich Fibrin on Septoplasty :A Comparative Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty

Detailed description

Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction. Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines. Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.

Conditions

• Nasal Septum; Deviation
• Nasal Septal Srur

Interventions

Type	Name	Description
OTHER	Effect of Platelet Rich Fibrin on Septoplasty	it is a randomized trial of usage of platelet rich fibrin in septoplasty

Timeline

• Start date: 2025-06-01
• Primary completion: 2026-01-01
• Completion: 2026-02-01
• First posted: 2025-05-30
• Last updated: 2025-05-30