NCT06992245

Characterization of Placental Diffusion

Characterization of Placental Diffusion in Women With Diabetes Using DW-MRI

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Hillel Yaffe Medical Center · Other Government
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

DW-MRI Allows a quantitative comparison of diffusion as an expression of tissue hypoxia. The investigators aim is to compare changes in placental diffusion in pregnant women with uncontrolled diabetes compared to healthy pregnant women using DW-MRI. The investigators hypothesize that placentas of diabetic mothers will show lower diffusion / perfusion compared to placentas of healthy women.

Detailed description

In highly uncontrolled diabetes there is an increased risk of intrauterine fetal death. The mechanism of fetal death is unknown and unpredictable. One of the theories points to hypoxia as a precursor to the death of the fetus in the womb. If the researchers succeed in predicting changes in the placenta with the help of MRI, it may be possible to understand the mechanism of fetal damage as well as in the future to develop a protocol for predicting pregnancies prone to fetal death in the womb.

Conditions

• Pregnancy in Diabetic
• Placenta Diseases

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	DW-MRI	Predict changes in ovarian diffusion using DW-MRI scan

Timeline

• Start date: 2023-07-06
• Primary completion: 2027-12-01
• Completion: 2027-12-01
• First posted: 2025-05-28
• Last updated: 2025-12-24

Locations

1 site across 1 country: Israel