NCT06991530

Effect of Low Molecular Weight Heparin in Freeze-thaw Embryo Transfer Cycles in Women With Recurrent Implantation Failure

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 392 (actual)
• Sponsor: The Second Hospital of Shandong University · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Recurrent implantation failure (RIF) is considered a tough problem in assisted reproductive technology (ART) without effective treatments. The effect of low molecular weight heparin (LMWH) in pregnancy outcomes is controversial. In addition, there are few reports on the role of LMWH in population with RIF performing freeze-thaw embryo transfer (FET) cycles. The purpose of this study is to evaluate the effect of LMWH on pregnancy outcomes in women with FET cycles.

Conditions

• Low Molecular Weight Heparin
• Recurrent Implantation Failure
• FET
• IVF

Interventions

Type	Name	Description
DRUG	Low Molecular Weight Heparine	the LMWH group received injections of 4100 IU/d LMWH from the day of transplant

Timeline

• Start date: 2021-01-01
• Primary completion: 2024-11-30
• Completion: 2025-03-01
• First posted: 2025-05-28
• Last updated: 2025-08-12

Locations

1 site across 1 country: China