NCT06990477

Effect of EIT-guided PEEP in ARDS Patients With Higher Recruitability

Effect of EIT-guided PEEP On Clinical Outcomes in ARDS Patients With Higher Recuritability: a Pilot Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 264 (estimated)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 19 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. Our previous study found that moderate to severe ARDS patients with higher recruitability could benefit from EIT-guided PEEP. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes in patients with higher recruitability.

Conditions

• ARDS (Acute Respiratory Distress Syndrome)

Interventions

Type	Name	Description
DEVICE	EIT-guided PEEP	PEEP titrated by EIT will be performed with a decremental trial at the enrollment. Right after completing RM, PEEP will be set to 20cmH2O and then reduced in steps of 2cmH2O from 20 to 6 every 2min.

Timeline

• Start date: 2026-01-28
• Primary completion: 2029-01-19
• Completion: 2029-02-20
• First posted: 2025-05-25
• Last updated: 2026-02-02

Locations

3 sites across 1 country: China