NCT06989853

Methamphetamine and Troriluzole

Advancing Troiluzole as a Treatment for Methamphetamine Use Disorder: A Human Laboratory Study

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: William Stoops · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

This will be a human laboratory study evaluating the influence of troriluzole treatment on the effects of methamphetamine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.

Conditions

• Methamphetamine Use Disorder

Interventions

Type	Name	Description
DRUG	Placebo	The effects of placebo will be determined.
DRUG	Methamphetamine	Placebo and methamphetamine will be administered intravenously during experimental sessions.

Timeline

• Start date: 2025-08-25
• Primary completion: 2029-02-28
• Completion: 2029-02-28
• First posted: 2025-05-25
• Last updated: 2025-12-23

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study