NCT06988202

Comparative Effectiveness of Different Techniques for Repeat Ablation of Atrial Fibrillation

Comparative Effectiveness of Different Techniques for Repeat Ablation After Failed Initial Ablation for Persistent Atrial Fibrillation

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 630 (estimated)
• Sponsor: University of Rochester · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Atrial fibrillation (AF) is the most common type of irregular heartbeat doctors see. People with AF sometimes have a procedure called an ablation to help get their heart back into a normal rhythm. However, this treatment doesn't always work. This study is looking at whether adding an extra step to the usual ablation-specifically treating another area of the heart called the left atrial (LA) posterior wall-can help people feel better overall, compared to just repeating the standard pulmonary vein isolation ablation procedure.

Conditions

• Atrial Fibrillation (AF)

Interventions

Type	Name	Description
PROCEDURE	Pulmonary Vein Isolation (PVI) without Left Atrial Posterior Wall Isolation (PWI)	A doctor inserts a thin, flexible tube (called a catheter) through a blood vessel, usually in the groin, and guides it to the heart. Once the catheter is in place, the doctor uses pulsed field electroporation, heat (radiofrequency) or cold (cryoablation) to create small scars in the area where the pulmonary veins connect to the left atrium of the heart. These scars block the faulty electrical signals that cause AF, helping the heart maintain a normal rhythm.
PROCEDURE	Pulmonary Vein Isolation (PVI) with Left Atrial Posterior Wall Isolation (PWI)	PVI with an additional step where the doctor also isolates the back wall (posterior wall) of the left atrium.

Timeline

• Start date: 2026-03-18
• Primary completion: 2030-01-01
• Completion: 2031-12-31
• First posted: 2025-05-23
• Last updated: 2026-03-23

Locations

1 site across 1 country: United States