NCT06986525

Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions

A Prospective Split-Mouth Clinical Study Comparing Coronally Advanced Flap and Tunnel Techniques Combined With Platelet-Rich Fibrin in the Treatment of Multiple Gingival Recessions

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Pamukkale University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II gingival recessions. Eleven participants with bilateral defects will be treated using a split-mouth design. Periodontal parameters will be assessed at baseline, 3 months, and 6 months.

Detailed description

The objective of this prospective clinical trial is to compare two mucogingival surgical techniques-coronally advanced flap (CAF) and tunnel technique-used in combination with platelet-rich fibrin (PRF) for treating multiple Miller Class I-II gingival recessions. Eleven systemically healthy participants with bilateral gingival recessions will be enrolled. CAF+PRF will be applied on one side, and Tunnel+PRF on the contralateral side. Clinical parameters including plaque index, gingival index, bleeding on probing, probing depth, clinical attachment level, recession height and width, and keratinized tissue height will be recorded at baseline, 3 months, and 6 months. Root coverage outcomes and clinical attachment gain will be analyzed.

Conditions

• Gingival Recession

Interventions

Type	Name	Description
PROCEDURE	CAF with PRF	Coronally advanced flap technique will be performed to reposition the gingival margin coronally. Platelet-rich fibrin (PRF) membranes will be placed over the exposed root surfaces and stabilized with sutures.
PROCEDURE	Tunnel with PRF	A tunnel or subgingival pouch will be created using microsurgical instruments without vertical incisions. Platelet-rich fibrin (PRF) membranes will be inserted into the tunnel and the gingival tissue will be advanced coronally and sutured to cover the recession.

Timeline

• Start date: 2025-08-15
• Primary completion: 2026-03-15
• Completion: 2026-03-15
• First posted: 2025-05-23
• Last updated: 2025-08-17

Locations

1 site across 1 country: Turkey (Türkiye)