NCT06983444

Bipolar Resection vs Enucleation of Prostate

Bipolar Trans Urethral Resection of the Prostate (TURP) Versus Bipolar Enucleation of the Prostate in Treatment of Benign Prostatic Hyperplasia (BPH): A Prospective Randomized Comparative Clinical Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: South Valley University · Academic / Other
• Sex: Male
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate efficacy and safety of transurethral resection of the prostate and bipolar enucleation of the prostate.

Detailed description

Endoscopic management of benign prostatic hyperplasia (BPH), monopolar transurethral resection of the prostate (TURP) has been the gold standard for many years. Despite its promising efficacy in treating BPH, TURP is associated with a risk of significant complications and clinical limitations, including life-threatening events such as transurethral resection (TUR) syndrome, as well as high cost due to long hospital stay, long catheterization time and difficulty in management of large sized prostate so alternative surgical approaches have been explored. Minimally invasive approaches achieve equal efficiency to standard resection, but with a more favorable safety and less complications. Anatomical enucleation of the prostate using Bipolar or Laser-based approaches such as holmium laser have been introduced with success and the efficacy and safety of these procedure has led to the integration into several international guidelines. Early results of bipolar enucleation resemble those reported for holmium laser procedure, Bipolar transurethral enucleation of the prostate was at least equally effective, and showed less complications, good hemostatic control and both shorter catheterization time and hospital stay than old standard procedure. A comparison between TURP and Bipolar enucleation of prostate allows us to investigate the true benefits and safety of each modality.

Conditions

• Benign Prostatic Hyperplasia (BPH) Requiring Surgical Resection
• Benign Prostatic Hyperplasia With Outflow Obstruction
• Benign Prostatic Hyperplasia With Symptomatic Lower Urinary Tract Symptoms
• Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms

Interventions

Type	Name	Description
PROCEDURE	TURP	Using bipolar loop diathermy via cystoscopy, excess prostate tissue is resected piecemeal to remove obstruction to the prostatic urethra due to BPH.
PROCEDURE	TUEP	Using bipolar enucleation loop diathermy via cystoscopy, to anatomically enucleate prostate.

Timeline

• Start date: 2025-06-01
• Primary completion: 2026-06-30
• Completion: 2026-07-01
• First posted: 2025-05-21
• Last updated: 2025-05-21

Locations

1 site across 1 country: Egypt