NCT06983379

Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders

Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders: An Original Clinical Investigation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 68 (actual)
• Sponsor: Mardin Artuklu University · Academic / Other
• Sex: All
• Age: 0 Years – 18 Years
• Healthy volunteers: Accepted

Summary

Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders

Detailed description

Introduction: The etiology of Autism Spectrum Disorder (ASD) is thought to be complex. Increasing evidence in the literature shows that oxidative stress plays a role in the development and prognosis of autism. In our study, investigators aimed to investigate whether thiol disulfide balance, which is a new marker of oxidative stress, is different from that in normal children with autism spectrum disorder. Methods A total of 68 children, 38 with autism spectrum disorder and 30 healthy controls, were included in the study. Dynamic thiol balance, total oxidant status, total antioxidant status, ischemia-modified albumin, paraoxonase 1, and arylesterase activities were measured using colorimetric methods. Routine biochemical parameters were obtained from their files and evaluated.

Conditions

• Autism Spectrum Disorders

Timeline

• Start date: 2020-01-03
• Primary completion: 2021-06-30
• Completion: 2023-01-30
• First posted: 2025-05-21
• Last updated: 2025-05-21

Locations

1 site across 1 country: Turkey (Türkiye)