NCT06979882

Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Intestinal Carcinoma

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (ORR) assessed by contrast-enhanced CT/MRI and levels of serum tumor markers. Secondary endpoints include: (a) time-dependent association between methylation fluctuation patterns and progression-free survival (PFS), (b) comparative diagnostic accuracy of methylation indices versus conventional biomarkers, and (c) feasibility of using methylation thresholds to guide adaptive therapy modification.

Conditions

• Intestinal Cancer

Interventions

Type	Name	Description
OTHER	Multi-gene methylation testing	Undergo multi-gene methylation testing in blood during follow-up
OTHER	Multi-gene methylation testing	Undergo multi-gene methylation testing in blood during follow-up
OTHER	Multi-gene methylation testing	Undergo multi-gene methylation testing in blood during follow-up

Timeline

• Start date: 2025-05-25
• Primary completion: 2030-03-01
• Completion: 2030-03-01
• First posted: 2025-05-20
• Last updated: 2025-05-20

Locations

2 sites across 1 country: China