NCT06979141

Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia

Comparative Study Between Efficacy of Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression During General Anesthetic Emergence

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, MgSO4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.

Conditions

• Cough

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Patients will receive 0.5 μg/kg dexmedetomidine in 10ml normal saline 10 min before the end of surgery.
DRUG	Magnesium sulfate	Patients will receive 30 mg/kg IV magnesium sulfate 50% 10 min before the end of surgery.
DRUG	Lidocaine	Patients will receive lidocaine 1.5 mg/kg lidocaine 10 min before the end of surgery.
DRUG	normal saline	Patients will receive 10 ml normal saline 10 min before the end of surgery.

Timeline

• Start date: 2025-06-02
• Primary completion: 2026-06-01
• Completion: 2026-08-01
• First posted: 2025-05-18
• Last updated: 2025-06-11

Locations

1 site across 1 country: Egypt