Trials / Not Yet Recruiting
Not Yet RecruitingNCT06978946
Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients
Clinical Efficacy and Safety of Deep Cervical Lymphaticovenous Anastomosis (DLVA) in Moderate-to-Severe Neurodegenerative Dementia
- Status
- Not Yet Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 85 (estimated)
- Sponsor
- RenJi Hospital · Academic / Other
- Sex
- All
- Age
- 50 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
This clinical trial aims to evaluate the clinical efficacy and safety of Deep Cervical Lymphaticovenous Anastomosis (DLVA) in patients aged 50-80 with moderate to severe neurodegenerative dementia. Participants will undergo surgical treatment, followed by cognitive assessments, PET/MRI scans, lymph fluid/cerebrospinal fluid collection, and blood tests. Additionally, the study will perform an in-depth analysis of DLVA's therapeutic mechanisms using multimodal imaging and molecular biology experiments.
Conditions
- Alzheimer Disease
- Lewy Body Dementia (LBD)
- Frontotemporal Dementia (FTD)
- Dementia
- Parkinsons Disease With Dementia (PDD)
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Deep Cervical Lymphaticovenous Anastomosis(DLVA) | This surgery will enhance the drainage of cerebral lymphatic fluid by surgically establishing a connection between lymphatic vessels and veins in the neck |
Timeline
- Start date
- 2025-05-28
- Primary completion
- 2027-02-01
- Completion
- 2027-02-28
- First posted
- 2025-05-18
- Last updated
- 2025-05-28
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06978946. Inclusion in this directory is not an endorsement.