NCT06978010

Efficacy of Platelet-rich Plasma in Improving Postoperative Scarring After Cesarean Delivery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Saint Andrew Hospital Constanta · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Cesarean section often leads to postoperative scarring, which can impact both physical and psychological well-being. Platelet-rich plasma (PRP), rich in growth factors, is used in regenerative medicine to promote healing and reduce inflammation.

Detailed description

Background: Cesarean section often leads to postoperative scarring, which can impact both physical and psychological well-being. Platelet-rich plasma (PRP), rich in growth factors, is used in regenerative medicine to promote healing and reduce inflammation. Objective: To evaluate the efficacy of intraoperative PRP in accelerating scar healing after cesarean section, using: Six visual scar assessment scales (Manchester, POSAS, Vancouver, VAS, NRS, REEDA) Hematological parameters (hemoglobin, hematocrit, leukocytes, platelets) Methods: Design: Prospective clinical study, 100 patients undergoing cesarean section with intraoperative PRP. Intervention: 10 ml PRP administered intraoperatively (5 ml before hysterography, 5 ml subcutaneously before skin closure). Assessments: Scar evaluation at day 7 and day 40 post-op using six scar scales; hematological parameters measured at both time points. Statistics: Wilcoxon paired samples test and Pearson correlation.

Conditions

• Cesarean Section Wound
• Platelet-rich Plasma (PRP)
• Regenerative Medicine

Interventions

Type	Name	Description
OTHER	Platelet-Rich Plasma (PRP) intraoperatively	Patients receive platelet-rich plasma (PRP) intraoperatively during cesarean section (5 ml before hysterography, 5 ml subcutaneously before skin closure).

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-01-31
• Completion: 2024-01-31
• First posted: 2025-05-18
• Last updated: 2025-05-21

Locations

1 site across 1 country: Romania