NCT06977347

Appropriateness of Antibiotic Combination Therapy for Severe Community-acquired Pneumonia in South Korea

Verification of Anti-pseudomonal Antibiotic Combination Therapy in Severe Community-acquired Pneumonia in South Korea: A Randomized-controlled Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: CHOSEOK YOON · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This study aims to provide high-level evidence for appropriate empirical antibiotic use tailored to the clinical reality in Korea by conducting a randomized controlled trial comparing monotherapy with piperacillin/tazobactam and combination therapy with piperacillin/tazobactam plus a fluoroquinolone in patients with severe community-acquired pneumonia.

Conditions

• Severe Community-acquired Pneumonia (sCAP)

Interventions

Type	Name	Description
DRUG	Piperacillin/Tazobactam	Piperacillin/tazobactam: 4.5g IV q6h (over 3h)
DRUG	Piperacillin/tazobactam + Levofloxacin	Piperacillin/tazobactam: 4.5g IV q6h (over 3h) \+ Levofloxacin 750mg IV q24h (over 30min)

Timeline

• Start date: 2025-06-15
• Primary completion: 2026-12-31
• Completion: 2027-02-01
• First posted: 2025-05-18
• Last updated: 2025-05-18

Locations

1 site across 1 country: South Korea