Trials / Not Yet Recruiting
Not Yet RecruitingNCT06977282
The 'Bone-Brain' Crosstalk Mechanism of Subchondral Bone Nociceptive Sensitization Activating SPP1-Positive Microglia in the vlPAG Region Elucidates the Theoretical Connotation of Treating Knee Osteoarthritis Based on Kidney Differentiation
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 120 (estimated)
- Sponsor
- Jinchao Xu · Academic / Other
- Sex
- All
- Age
- 60 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
The aim of this observational study is to investigate the relationship between pain severity and alterations in bone-derived and brain-derived signaling molecules (including serum neurotransmitters and inflammatory cytokines), as well as structural and functional changes in the ventrolateral periaqueductal gray (vlPAG) region in patients with kidney-deficiency type knee osteoarthritis (KOA). The central question it seeks to address is whether changes in these signaling molecules and vlPAG alterations are associated with the degree of pain. Patients scheduled to undergo total knee arthroplasty (TKA) due to KOA will be enrolled prior to surgery. Before the operation, they will undergo questionnaire assessments, physical examinations, imaging evaluations, and blood sample collection. The resected tibial plateau tissue obtained during surgery will be used for subsequent laboratory analyses.
Conditions
Timeline
- Start date
- 2025-06-15
- Primary completion
- 2026-12-30
- Completion
- 2026-12-30
- First posted
- 2025-05-18
- Last updated
- 2025-05-18
Source: ClinicalTrials.gov record NCT06977282. Inclusion in this directory is not an endorsement.