NCT06976996

Efficacy of Esketamine Combined With Different General Anesthetics on Quality of Postoperative Recovery

Efficacy of Subanesthetic Dose of Esketamine Combined With Different General Anesthetics on Quality of Early Postoperative Recovery in Patients Undergoing Painless Gastrointestinal Endoscopy

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 190 (estimated)
• Sponsor: Northern Jiangsu People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To explore the effect of subanesthetic-dose esketamine combined with different general anesthetic drugs on the quality of postoperative recovery in patients undergoing painless gastrointestinal endoscopy.

Detailed description

In this study, we planned to conduct a single-center, prospective, randomized, controlled, double-blind clinical trial to explore the effect of subanesthetic dose esketamine combined with different general anesthesia drugs on the postoperative recovery quality of patients undergoing painless gastrointestinal endoscopy combined with several commonly used intravenous general anesthesia drugs, aiming at gastroscopy combined with colonoscopy, a representative type of diagnosis and treatment of painless and comfortable anesthesia, and to provide more evidence-based medical evidence for clinical work.

Conditions

• Quality of Postoperative Recovery

Interventions

Type	Name	Description
DRUG	normal saline	normal saline (0.15 ml/kg)
DRUG	esketamine	esketamine (0.15 mg/kg)
DRUG	propofol	propofol (2 mg/kg)
DRUG	etomidate-ciprofol (EC) mixture	etomidate-ciprofol (EC) mixture (0.2 ml/kg)
DRUG	ciprofol	ciprofol (0.5 mg/kg)
DRUG	etomidate-propofol (EP) mixture	etomidate-propofol (EP) mixture (0.2 ml/kg)

Timeline

• Start date: 2025-03-16
• Primary completion: 2025-12-15
• Completion: 2025-12-15
• First posted: 2025-05-16
• Last updated: 2025-05-16

Locations

1 site across 1 country: China