NCT06976606

A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM

An Observational Study to Assess Real-world Patient Characteristics, Clinical Course, and Treatment Patterns for Symptomatic Patients With Arrhythmogenic Cardiomyopathy (ACM) Due To a PlaKoPhilin-2 Pathogenic Variant (PKP2)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Lexeo Therapeutics · Industry
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

An observational study to assess real-world patient characteristics and clinical course of disease in participants with PKP2-ACM.

Detailed description

SNAPSHOT-PKP2 is an observational, multicenter study that consists of 2 parts, a retrospective EMR review (up to 2 years) and a prospective observational study (1 year), to evaluate the clinical burden of illness of patients with PKP2-ACM, and to prospectively evaluate changes in key cardiac parameters and patient-reported outcome measures (PROMs) associated with PKP2-ACM progression.

Conditions

• Arrhythmogenic Cardiomyopathy
• PKP2-ACM
• PKP2-ARVC

Timeline

• Start date: 2024-01-23
• Primary completion: 2027-07-01
• Completion: 2027-09-01
• First posted: 2025-05-16
• Last updated: 2025-05-16

Locations

6 sites across 1 country: United States