NCT06976034

oCular Examination at Cell RESolution With Optical TransmissionTomography

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Understanding the pathogenesis of eye diseases has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems, such as optical coherence tomography (OCT), are limited in terms of resolution, acquisition speed or access to certain eye functions. Our team has participated in the development of a new generation of imaging technology known as optical transmission tomography (OTT), which enables imaging of the anterior parts of the eye with high cellular resolution, a wide field of view and reduced examination delay.

Detailed description

For healthy subjects: an imaging examination using each system (OTT + OCT + specular microscopy) will be carried out twice, at an interval of two (2) years (inclusion visit + visit at 24 months). Several imaging images will be taken by two different operators during these sessions. For patients: an imaging examination using each system (OTT + OCT + specular microscopy) will be carried out by two different operators, and several imaging images will be taken. These examinations will be carried out at the inclusion visit and at the following visits according to the disease assessment schedule, lasting up to a maximum of 4 years.

Conditions

• Glaucoma Associated With Other Ocular Disorders

Interventions

Type	Name	Description
DEVICE	Optical Transmission Tomography (OTT)	Multiple imaging sessions added by research using the systems described (OTT) will be carried out by two different operators at different positions during these sessions.
DEVICE	Optical Coherence Tomography (OCT)	Multiple imaging sessions (OCT) already used in standard of care will be performed by two different operators at different positions during these sessions.
DEVICE	Specular Microscopy (SM)	Multiple imaging sessions (SM) already used in standard of care will be performed by two different operators at different positions during these sessions.

Timeline

• Start date: 2024-11-12
• Primary completion: 2029-11-12
• Completion: 2029-11-12
• First posted: 2025-05-16
• Last updated: 2025-05-16

Locations

1 site across 1 country: France