NCT06974994

Resilience to Antibiotic-induced Obesogenic Microbiota: Discovering Mechanism of Microbiota Modulation

Resilience to Antibiotic-induced Obesogenic Microbiota Vertically Transferred to the Neonatal Gut: Discovering Mechanism of Microbiota Modulation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 125 (estimated)
• Sponsor: Turku University Hospital · Other Government
• Sex: All
• Age: 2 Hours
• Healthy volunteers: Not accepted

Summary

The aim is to study whether the microbiota of children who are exposed to antibiotics at birth could be modified by synbiotic supplement and thereby reduce the risk of obesity, chronic diseases and respiratory tract infections. A total of 125 mother-child pairs will be recruited in this randomized, double-blind, placebo-controlled study. Infants are randomized to receive either a synbiotic supplement or a placebo for 2 months, after which their growth and morbidity will be monitored at the research clinic for 2 years.

Conditions

• Healthy Newborn Infants

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Synbiotic Supplement	Bifidobacterium bifidum and human milk oligosaccharides (HMOs)
OTHER	Placebo	Maltodextrin

Timeline

• Start date: 2024-05-08
• Primary completion: 2029-12-01
• Completion: 2029-12-01
• First posted: 2025-05-16
• Last updated: 2025-05-16

Locations

1 site across 1 country: Finland