NCT06974279

Post-Stroke Aphasia TMS

Precision Neuromodulation in Post-Stroke Aphasia Using TMS

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).

Detailed description

In this project, the investigator will use functional neuroimaging and inhibitory TMS to determine precise therapy-responsive targets for excitatory TMS therapy with SFA. One group of stroke survivors will receive SFA + TMS targeting the precision site, and another group will receive SFA + TMS targeting a control site. The primary outcome will be changes in picture naming accuracy. We expect that excitatory TMS targeting a precision site would result in larger improvements in naming accuracy than TMS targeting a control site. Results will provide the efficacy of precision TMS in post-stroke aphasia.

Conditions

• Aphasia
• Stroke
• Language

Interventions

Type	Name	Description
DEVICE	Precision TMS with SFA	Excitatory TMS delivered using a precision site finding approach and intermittent theta burst stimulation protocol
DEVICE	Control TMS with SFA	Excitatory TMS using intermittent theta burst stimulation delivered to a control vertex site.

Timeline

• Start date: 2025-09-01
• Primary completion: 2036-12-31
• Completion: 2036-12-31
• First posted: 2025-05-15
• Last updated: 2025-09-19

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study