NCT06973980

HIIT in Sedentary Obese Adults: Effects on Metabolic Risk, Body Composition, and FABP4

The Effect of High-Intensity Interval Training on Cardiometabolic Risk Factors, Body Composition, and Plasma FABP4 Levels in Sedentary Obese Adults.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (estimated)
• Sponsor: Eastern Mediterranean University · Academic / Other
• Sex: All
• Age: 20 Years – 35 Years
• Healthy volunteers: Accepted

Summary

It is aimed to investigate the responses of Fatty Acid Binding Protein 4 (FABP4), which has been discovered as a novel biomarker of obesity and metabolic diseases, to regular exercise training. The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.

Detailed description

Fatty acid binding proteins are intracellular proteins involved in the transport of fatty acids and are particularly associated with lipolytic activity. These proteins constitute a group of molecules that regulate intracellular lipid responses and are linked to metabolic and inflammatory pathways. Studies have shown that FABP4 is associated with hypertension, insulin resistance, obesity, and stroke. Inhibition of FABP4 synthesis has emerged as a promising strategy for the treatment of obesity-related conditions, particularly insulin resistance and diabetes, and it is emphasized that exercise models to suppress FABP4 should be further investigated. The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults. Hypotheses: H01: HIIT has no effect on cardiometabolic risk factors in sedentary obese adults. H02: HIIT has no effect on body composition in sedentary obese adults. H03: HIIT has no effect on plasma FABP4 levels in sedentary obese adults.

Conditions

• High-Intensity Interval Training

Interventions

Type	Name	Description
OTHER	Exercise	The exercises will be applied only to the intervention group for 12 weeks and will be progressively intensified every 4 weeks.

Timeline

• Start date: 2025-03-01
• Primary completion: 2025-07-01
• Completion: 2025-09-01
• First posted: 2025-05-15
• Last updated: 2025-05-15

Locations

1 site across 1 country: Cyprus