NCT06973499

Exploratory Study of the Microbiome of Upper Gastrointestinal in the Pathogenesis of Multiple Primary Lung Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Beijing Haidian Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is an exploratory, single-center, being conducted at Beijing Haidian Hospital in order to detect the relationship between microbiome of upper gastrointestinal and pathogenesis of multiple primary lung cancer.

Detailed description

This study intends to analyze the bacterial community structure of respiratory tract, upper digestive tract, lesion and adjacent to cancer in patients with multiple primary lung cancer, and to explore the association between upper digestive tract bacterial community and lung microecology, in order to find the characteristics of upper digestive tract bacterial strains involved in regulating lung cancer microenvironment, and explore the possible interaction mechanism between upper digestive tract bacterial community and lung cancer gene mutation.

Conditions

• Multiple Primary Lung Cancer
• Microbial Colonization

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Microbiome Profiling and Symptom Assessment	GERD symptom assessment: Standardized GERD-Q questionnaire to evaluate reflux symptoms (heartburn, acid regurgitation) and high-risk behaviors. Microbiome analysis: 16S rDNA sequencing of upper gastrointestinal and intratumoral microbiota.

Timeline

• Start date: 2023-01-06
• Primary completion: 2024-05-30
• Completion: 2024-12-25
• First posted: 2025-05-15
• Last updated: 2025-05-15

Locations

1 site across 1 country: China