NCT06969872

Effects of Probiotics on Symptoms of Constipation in Adults With Functional Constipation

The Effects of ABKefir on Functional Constipation in Subjects: a Randomized, Double-blind, Placebo-controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 165 (estimated)
• Sponsor: Chung Shan Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study was to evaluate the efficacy of 1 capsules of ABKefir per day on symptoms of constipation in subjects with functional constipation by clinical trial.

Detailed description

This randomized, placebo-controlled clinical trial will be conduct for 8 weeks with one hundred and sixty-five adults. Subjects will be recruited and randomly assigned into three groups: (1) placebo, n = 55; (2) low dose of ABKefir , n = 55; (3) high dose of ABKefir, n = 55. During the first 4 weeks of supplement, the subjects should take one capsule of placebo or ABKefir daily. Apart from containing no probiotics, the content of placebo is same as ABKefir. After that, the next 4 weeks is to have a follow-up of subjects. During this phase, subjects don't need to supplement. Subjects should complete the assessment of anthropometric measurement, defecation questionnaire , food record, feces and blood collection at week 0, 4 and week 8.

Conditions

• Functional Constipation (FC)

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Take a capsule of placebo within 30 minutes after breakfast, and once a day.
DIETARY_SUPPLEMENT	Probiotics (ABKefir)	Take a capsule of ABKefir within 30 minutes after breakfast, and once a day.

Timeline

• Start date: 2024-12-27
• Primary completion: 2026-09-30
• Completion: 2026-09-30
• First posted: 2025-05-14
• Last updated: 2026-01-02

Locations

1 site across 1 country: Taiwan