NCT06969846

Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Louis Stokes VA Medical Center · Federal
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies. Directly stimulating the carotid sinus nerve (CSN) is known to potentially reduce blood pressure (BP) but its clinical efficacy has not been consistently demonstrated with existing electrode technologies in humans. We investigated the effect of acute direct CSN stimulation on BP and HR in anesthetized humans using an application-specific multi-contact electrode.

Conditions

• HTN-Hypertension
• Blood Pressure Management

Interventions

Type	Name	Description
DEVICE	CSN electrode was implanted around tissue including CSN branches	Using a novel surgical approach, a custom electrode was implanted around tissue including CSN branches in anesthetized adults. Following functional mapping, presumed baroafferent fibers were identified via response and stimulated. Outcome measures included change in systolic BP (SBP), diastolic BP (DBP), and heart rate (HR) during and after stimulation using multi-level modeling. Secondarily, dose dependency was examined.

Timeline

• Start date: 2020-04-03
• Primary completion: 2022-08-12
• Completion: 2024-08-12
• First posted: 2025-05-14
• Last updated: 2025-05-14

Locations

1 site across 1 country: United States