Trials / Completed
CompletedNCT06969768
Proteogenomics for Follicular Cell-derived Thyroid Cancer: Development of a Classification and Prognosis Prediction Model
Integrative Multi-Omics Refines the Molecular Subtypes of Thyroid Cancers and Enhances Cancer-Progression Prediction
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 275 (actual)
- Sponsor
- Seoul National University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to refine the molecular classification of thyroid cancer (TC) using a multi-omics approach. By identifying a novel gene set and applying decision-tree modeling, the study seeks to improve diagnostic accuracy and predict tumor progression in BRAFV600E-like and RAS-like TC subtypes. Protein biomarkers were validated via immunohistochemistry (IHC), with findings confirmed across external datasets.
Conditions
Timeline
- Start date
- 2018-02-21
- Primary completion
- 2021-02-21
- Completion
- 2024-02-28
- First posted
- 2025-05-14
- Last updated
- 2025-05-14
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT06969768. Inclusion in this directory is not an endorsement.