NCT06969131

Current Role of Pentafecta Outcomes in Open and Laparoscopic Partial Nephrectomy for Localized Renal Tumors

The Current Role of Pentafecta Outcomes in Open and Laparoscopic Partial Nephrectomy for Localized Renal Tumors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: South Valley University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to identify predictive factors associated with the achievement of pentafecta outcomes following partial nephrectomy.

Detailed description

Partial nephrectomy (PN) is widely considered the preferred treatment for clinical T1 (cT1) renal masses, primarily because it preserves kidney function more effectively than radical nephrectomy. The trifecta metric includes three components: warm ischemia time (WIT) of ≤ 25 minutes or cold ischemia time (CIT) of ≤ 60 minutes, negative surgical margins, and the absence of perioperative major complications. The pentafecta expands upon these criteria by adding two additional parameters: preservation of ≥ 90% of the estimated glomerular filtration rate (eGFR) and no progression in chronic kidney disease (CKD) stage within 12 months postoperatively.

Conditions

• Pentafecta
• Laparoscopic
• Partial Nephrectomy
• Renal Tumors

Interventions

Type	Name	Description
PROCEDURE	Open Partial Nephrectomy	Patients underwent open partial nephrectomy.
PROCEDURE	Laparoscopic Partial Nephrectomy	Patients underwent laparoscopic partial nephrectomy.

Timeline

• Start date: 2022-05-01
• Primary completion: 2024-05-01
• Completion: 2024-05-01
• First posted: 2025-05-13
• Last updated: 2025-05-13

Locations

1 site across 1 country: Egypt