NCT06968936

Long-term Outcomes Sub-Study of Preoperative Combined Iron Therapy

Long-term Outcomes Sub-Study of Preoperative Combined Iron Therapy in Anemic Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This is a sub-study of the Preoperative Combined Iron Therapy trail in which some participants will be additionally randomized to combined iron supplementation or standarded treatment control to evaluate the impact on long-term outcomes.

Conditions

• Anemia
• Iron Deficiencies
• Cardiac Surgery

Interventions

Type	Name	Description
DRUG	Sucrose Iron，subcutaneous recombinant human erythropoietin，intravenous vitamin C	Patients in the experimental group will receive a combination therapy consisting of intravenous sucrose iron (200 mg), subcutaneous recombinant human erythropoietin (150 IU/kg), and intravenous vitamin C (2 g), administered once daily for three consecutive days within the week prior to surgery.
PROCEDURE	Routine perioperative management	Routine perioperative management based on clinical judgment, including observation, monitoring, and standard nursing practices.

Timeline

• Start date: 2026-03-27
• Primary completion: 2029-06-30
• Completion: 2029-06-30
• First posted: 2025-05-13
• Last updated: 2026-04-13

Locations

1 site across 1 country: China